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040 _aDLC
_bEn
_cDLC
050 _aDUCE QP519.9.L55 A73
100 _aArdrey, R. E.
_qRobert E. Ardrey
245 _aLiquid chromatography-mass spectrometry :
_ban introduction /
_cby Robert E. Ardrey
260 _aNew York:
_bJohn Wiley & Sons Ltd,
_c2003.
300 _axviii, 276 p. :
_bill. ;
_c23 cm.
440 _aAnalytical techniques in the sciences
500 _aIncludes bibliographical references and index.
520 _aThis book provides a clear and practical introduction to liquid chromatography–mass spectrometry (LC–MS), one of the most important analytical techniques used in pharmaceutical, biomedical, environmental, and chemical research. Ardrey explains the fundamental principles of both liquid chromatography (LC) and mass spectrometry (MS), showing how their combination enables the separation, identification, and quantification of complex mixtures. The text covers the essential components of LC–MS instrumentation, including chromatographic systems, ionization techniques such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), mass analyzers, detectors, and data interpretation. Special attention is given to method development, sample preparation, optimization of operating conditions, and troubleshooting common analytical problems. Designed for students, researchers, and laboratory scientists, the book emphasizes practical applications of LC–MS in pharmaceutical analysis, drug metabolism studies, biomolecule characterization, and trace-level chemical analysis. Through accessible explanations and real-world examples, it helps readers understand both the theoretical basis and practical operation of LC–MS systems, making it a valuable introductory resource for those entering the field of analytical chemistry. Keywords: Liquid chromatography–mass spectrometry (LC–MS), analytical chemistry, mass spectrometry, chromatography, electrospray ionization, pharmaceutical analysis, method development, instrumentation, chemical analysis, bioanalysis.
_uhttp://172.20.27.22:4000/handle/123456789/186
856 _yhttp://172.20.27.22:4000/handle/123456789/186
_uhttp://172.20.27.22:4000/handle/123456789/186
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_cBK
_n0
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