02426nam a22002177a 4500 OSt 20260609112905.0 260609b |||||||| |||| 00| 0 eng d 0-471-49799-1 DLC En DLC DUCE QP519.9.L55 A73 Ardrey, R. E. Robert E. Ardrey Liquid chromatography-mass spectrometry : an introduction / by Robert E. Ardrey New York: John Wiley & Sons Ltd, 2003. xviii, 276 p. : ill. ; 23 cm. Analytical techniques in the sciences Includes bibliographical references and index. This book provides a clear and practical introduction to liquid chromatography–mass spectrometry (LC–MS), one of the most important analytical techniques used in pharmaceutical, biomedical, environmental, and chemical research. Ardrey explains the fundamental principles of both liquid chromatography (LC) and mass spectrometry (MS), showing how their combination enables the separation, identification, and quantification of complex mixtures. The text covers the essential components of LC–MS instrumentation, including chromatographic systems, ionization techniques such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), mass analyzers, detectors, and data interpretation. Special attention is given to method development, sample preparation, optimization of operating conditions, and troubleshooting common analytical problems. Designed for students, researchers, and laboratory scientists, the book emphasizes practical applications of LC–MS in pharmaceutical analysis, drug metabolism studies, biomolecule characterization, and trace-level chemical analysis. Through accessible explanations and real-world examples, it helps readers understand both the theoretical basis and practical operation of LC–MS systems, making it a valuable introductory resource for those entering the field of analytical chemistry. Keywords: Liquid chromatography–mass spectrometry (LC–MS), analytical chemistry, mass spectrometry, chromatography, electrospray ionization, pharmaceutical analysis, method development, instrumentation, chemical analysis, bioanalysis. http://172.20.27.22:4000/handle/123456789/186 http://172.20.27.22:4000/handle/123456789/186 http://172.20.27.22:4000/handle/123456789/186 lcc BK 0 4457 4457 0 0 lcc 0 0 SCI DL DL SCI QP31–ZF11 2026-06-09 0 DUCE QP519.9.L55 A73 2026-06-09 11:30:00 2026-06-09 BK