02366nam a22001937a 4500003000400000005001700004008004100021020001800062040001700080050002500097100003600122245008800158260004500246300003700291440004200328500005100370520165400421856009702075OSt20260609112905.0260609b        |||||||| |||| 00| 0 eng d  a0-471-49799-1  aDLCbEncDLC  aDUCE QP519.9.L55 A73  aArdrey, R. E.qRobert E. Ardrey  aLiquid chromatography-mass spectrometry : ban introduction / cby Robert E. Ardrey  aNew York:bJohn Wiley & Sons Ltd,c2003.  axviii, 276 p. :bill. ; c23 cm.  aAnalytical techniques in the sciences  aIncludes bibliographical references and index.  aThis book provides a clear and practical introduction to liquid chromatography–mass spectrometry (LC–MS), one of the most important analytical techniques used in pharmaceutical, biomedical, environmental, and chemical research. Ardrey explains the fundamental principles of both liquid chromatography (LC) and mass spectrometry (MS), showing how their combination enables the separation, identification, and quantification of complex mixtures.

The text covers the essential components of LC–MS instrumentation, including chromatographic systems, ionization techniques such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), mass analyzers, detectors, and data interpretation. Special attention is given to method development, sample preparation, optimization of operating conditions, and troubleshooting common analytical problems.

Designed for students, researchers, and laboratory scientists, the book emphasizes practical applications of LC–MS in pharmaceutical analysis, drug metabolism studies, biomolecule characterization, and trace-level chemical analysis. Through accessible explanations and real-world examples, it helps readers understand both the theoretical basis and practical operation of LC–MS systems, making it a valuable introductory resource for those entering the field of analytical chemistry.

Keywords: Liquid chromatography–mass spectrometry (LC–MS), analytical chemistry, mass spectrometry, chromatography, electrospray ionization, pharmaceutical analysis, method development, instrumentation, chemical analysis, bioanalysis.uhttp://172.20.27.22:4000/handle/123456789/186  yhttp://172.20.27.22:4000/handle/123456789/186uhttp://172.20.27.22:4000/handle/123456789/186