Liquid chromatography-mass spectrometry : an introduction /
by Robert E. Ardrey
- New York: John Wiley & Sons Ltd, 2003.
- xviii, 276 p. : ill. ; 23 cm.
- Analytical techniques in the sciences .
Includes bibliographical references and index.
This book provides a clear and practical introduction to liquid chromatography–mass spectrometry (LC–MS), one of the most important analytical techniques used in pharmaceutical, biomedical, environmental, and chemical research. Ardrey explains the fundamental principles of both liquid chromatography (LC) and mass spectrometry (MS), showing how their combination enables the separation, identification, and quantification of complex mixtures.
The text covers the essential components of LC–MS instrumentation, including chromatographic systems, ionization techniques such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), mass analyzers, detectors, and data interpretation. Special attention is given to method development, sample preparation, optimization of operating conditions, and troubleshooting common analytical problems.
Designed for students, researchers, and laboratory scientists, the book emphasizes practical applications of LC–MS in pharmaceutical analysis, drug metabolism studies, biomolecule characterization, and trace-level chemical analysis. Through accessible explanations and real-world examples, it helps readers understand both the theoretical basis and practical operation of LC–MS systems, making it a valuable introductory resource for those entering the field of analytical chemistry.